Glutamine antagonist DRP-104 suppresses tumor growth and enhances response to checkpoint blockade in KEAP1 mutant lung cancer
R. Pillai, S. E. LeBoeuf, Y. Hao, C. New, J. Blum, A. Rashidfarrokhi, S. M. Huang, C. Bahamon, W. L. Wu, B. Karadal-Ferrena, A. Herrera, E. Ivanova, M. Cross, J. P. Bossowski, H. Ding, , T. Papagiannakopoulos
This study shows that DRP-104, a glutamine antagonist, suppresses KEAP1 mutant lung tumor growth and enhances response to checkpoint blockade by inhibiting glutamine metabolism and improving T cell function.
bioRxiv · Jun 27, 2023 · PreprintCancer Biology