H. Ding

Bioadhesive Hydrogel-Coupled and Miniaturized Ultrasound Transducer System for Long-Term, Wearable Neuromodulation

This paper develops a wearable ultrasound device with bioadhesive hydrogel for long-term neuromodulation, demonstrating its effectiveness in suppressing somatosensory responses over 28 days.

AB-free kava enhances resilience against the adverse health effects of tobacco smoke in mice

This study evaluates AB-free kava's effects on tobacco smoke-exposed mice, showing it mitigates health deficits with safety, suggesting potential for reducing tobacco-related harm.

Natural killer cell migration in HIV-infected individuals is inhibited by impairment of HIF-1alpha-mediated glycolysis

This study identifies that impaired NK cell migration in HIV-infected individuals is due to TIGIT inhibiting HIF-1-mediated glycolysis through PI3K/AKT/mTORC1 or ERK pathways.

New role of cardiomyocyte Bmal1 in the regulation of sex-specific heart transcriptomes

This study shows that cardiomyocyte Bmal1 is essential for sex-specific gene expression in the adult mouse heart, as its loss reduces sex differences in circadian transcriptomes.

Balance Between EGF/STAT1 and IFNγ/NRF2 Signaling Controls ECM1 Expression and Determines Hepatic Homeostasis versus Chronic Liver Disease

This study identifies EGF/STAT1 and IFNγ/NRF2 signaling pathways regulating ECM1 expression, showing their role in maintaining liver homeostasis versus promoting chronic liver disease.

General Capillary Endothelial Cells Undergo Reprogramming into Arterial Endothelial Cells in Pulmonary Hypertension through HIF-2α/Notch4 Pathway

The transcription factor Zeb2 drives differentiation of age-associated B cells

The paper identifies Zeb2 as a critical transcription factor driving age-associated B-cell differentiation and autoimmunity in humans and mice.

Retinoic acid generates a beneficial microenvironment for liver progenitor cell activation in acute liver failure

This study shows retinoic acid secreted by activated hepatic stellate cells promotes liver progenitor cell activation in acute liver failure, improving patient outcomes.

Battery-Free Optoelectronic Patch for Photodynamic and Light Therapies in Treating Bacteria-Infected Wounds

This paper introduces a battery-free optoelectronic patch for photodynamic and light therapies to treat bacterial infections, showing reduced bacterial load and enhanced tissue regeneration in animal models.

ECM1 Attenuates Hepatic Fibrosis by Interfering with Mediators of Latent TGF-β1 Activation

This study shows ECM1 prevents hepatic fibrosis by inhibiting TGF-β1 activation, with implications for developing safe anti-fibrotic therapies.

Quantitative label free mass spectrometry reveals content and signaling differences between neonatal and adult platelets

This study compares the proteome and phosphoproteome of neonatal and adult platelets, identifying significant differences in protein content and phosphorylation that suggest developmental variations in immune function and activation potential.

Multitask Learning of Longitudinal Circulating Biomarkers and Clinical Outcomes: Identification of Optimal Machine-Learning and Deep-Learning Models

This study evaluates machine learning and deep learning models for predicting clinical outcomes using high-dimensional longitudinal biomarker data from a lung cancer trial, finding that MFPCA-Cox outperforms other methods.

Glutamine antagonist DRP-104 suppresses tumor growth and enhances response to checkpoint blockade in KEAP1 mutant lung cancer

This study shows that DRP-104, a glutamine antagonist, suppresses KEAP1 mutant lung tumor growth and enhances response to checkpoint blockade by inhibiting glutamine metabolism and improving T cell function.

The maize PLASTID TERMINAL OXIDASE (PTOX) gene controls the carotenoid content of kernels.

This study identifies ZmPTOX1 as a key gene for carotenoid biosynthesis in maize kernels, showing that its disruption reduces carotenoid content while overexpression increases it, particularly beta-carotene.

Conformations of the Human Immunodeficiency Virus (HIV-1) Envelope Glycoproteins in Detergents and Styrene-Maleic Acid Lipid Particles (SMALPs)

This study compares the stability and conformation of HIV-1 Env in detergents versus SMA lipids, showing SMA preserves the pretriggered state better at room temperature.

E2F1 Mediates SOX17 Deficiency-Induced Pulmonary Hypertension

This study shows that SOX17 deficiency in endothelial cells causes pulmonary hypertension via E2F1 signaling, suggesting E2F1 as a therapeutic target in PAH.

Insulin determines the effects of TGF-beta on HNF4alpha transcription and epithelial-to-mesenchymal transition in hepatocytes

This study shows insulin prevents TGF-beta-induced EMT in hepatocytes by inhibiting SMAD2/3 binding to C/EBP and SNAI1 promoters, maintaining HNF4 expression.

Dysregulated Expression of Circadian Genes in Lymphoblastoid Cells of Patients with ASD

This study shows that circadian genes are dysregulated in ASD patients' lymphoblastoid cells, linked to sleep phenotypes and altered gene networks.

Human adenovirus infection induces the overexpression of CLOCK protein in human lymphoblast cells

This study shows human adenovirus infection increases CLOCK protein expression and circadian oscillation amplitude in lymphoblast cells.

Small CD4 mimetics sensitize HIV-1-infected macrophages to antibody-dependent cellular cytotoxicity

The paper shows that small CD4 mimetics expose ADCC epitopes on HIV-1-infected macrophages, making them susceptible to antibody-dependent cellular cytotoxicity.

JQ-1 ameliorates schistosomiasis liver granuloma in mice by suppressing male and female reproductive systems and egg development of Schistosoma japonicum

This study shows JQ-1 reduces liver granuloma size and egg production in Schistosoma japonicum-infected mice by inhibiting reproductive system development and gene expression.

Increased ketohexokinase-A governs fructose-induced podocyte hypertrophy by IL-6/STAT3 signaling activation

This study identifies that increased ketohexokinase-A promotes fructose-induced podocyte hypertrophy through activation of IL-6/STAT3 signaling.

Spike glycoprotein and host cell determinants of SARS-CoV-2 entry and cytopathic effects

This study identifies key features of the SARS-CoV-2 spike glycoprotein, including the furin cleavage site and D614G mutation, that influence viral infectivity, stability, and cytopathicity.

Transferrin receptor (Tfr1) ablation in satellite cells impacts skeletal muscle regeneration through the activation of ferroptosis

Conditional Tfr1 ablation in satellite cells causes ferroptosis, leading to skeletal muscle regeneration defects and labile iron accumulation, recapitulated in aged rodents.

JQ-1 ameliorates schistosomiasis liver fibrosis by suppressing JAK2 and STAT3 activation

This study shows JQ-1 reduces liver fibrosis in Schistosoma-infected mice by inhibiting JAK2/STAT3 signaling in hepatic stellate cells.

Human H-ferritin presenting RBM of spike glycoprotein as potential vaccine of SARS-CoV-2

This paper describes the design of a fusion protein using human ferritin to present the SARS-CoV-2 spike glycoprotein RBM, suggesting it as a potential vaccine candidate.

The PK/PD Integration and Resistance of Ti lmi cosin Against Mycoplasma hyopneumoniae

This study investigates the PK/PD relationship of tilmicosin against M. hyopneumoniae, identifies resistance mechanisms, and suggests optimal dosing regimens.

AFF3 and BACH2 are master regulators of metabolic inflexibility, β/α-cell transition, and dedifferentiation in type 2 diabetes

The paper identifies AFF3 and BACH2 as master regulators of metabolic inflexibility, β/α-cell transition, and dedifferentiation in type 2 diabetes using single-cell analysis of human islets.

Analysis of the Mutant Selection Window and Killing of Mycoplasma hyopneumoniae for Doxycycline, Tylosin, Danofloxacin, Tiamulin, and Valnemulin

This study evaluates the mutant selection window and killing effects of five antibiotics against Mycoplasma hyopneumoniae, finding that danofloxacin, tylosin, and doxycycline are more likely to promote resistance than tiamulin and valnemulin.

Nano immunoconjugates crossing blood-brain barrier activate local brain tumor immune system for glioma treatment

This study develops nano immunoconjugates that cross the blood-brain barrier to activate local immune responses against gliomas, improving survival in treated mice.