Cell BiologybioRxivPreprint
Loss of TP53 mediates suppression of Macrophage Effector Function via Extracellular Vesicles and PDL1 towards Resistance against Chemoimmunotherapy in B-cell malignancies
E. Izquierdo, D. Vorholt, B. Sackey…·C. Pallasch
This paper identifies that TP53 loss in B-cell lymphoma leads to resistance against chemoimmunotherapy by suppressing macrophage effector function through PDL1-expressing extracellular vesicles.
DOI 10.1101/2020.06.11.145268