M. Krueger

Rapid enzymatic detection of Shigatoxin-producing E. coli using fluorescence-labeled oligonucleotide substrates

This paper develops a rapid method to detect Shigatoxin-producing E. coli by measuring Stx activity using fluorescent oligonucleotide substrates.

Deciphering Cell-types and Gene Signatures Associated with Disease Activity in Rheumatoid Arthritis using Single Cell RNA-sequencing

This study uses single-cell RNA sequencing of PBMCs from RA patients and controls to identify disease-associated cell subsets and gene signatures linked to RA disease activity.

Pentose Phosphate Pathway Inhibition activates Macrophages towards phagocytic Lymphoma Cell Clearance

This study shows that inhibiting the pentose phosphate pathway enhances macrophage phagocytosis of lymphoma cells and improves survival in a mouse model.

Differential contribution of nitrifying prokaryotes to groundwater nitrification

The paper investigates the contribution of nitrifying prokaryotes to groundwater nitrification, finding that AOB dominate the first step of nitrification despite CMX's numerical predominance.

Deficiency in hyaluronan synthase 3 attenuates ruptures in a murine model of abdominal aortic aneurysms by reduced aortic monocyte infiltration

This study shows that deficiency in HAS3 reduces aortic ruptures in a murine AAA model by decreasing monocyte infiltration and ECM degradation.

Alteration of myocardial structure and function in RAF1associated Noonan syndrome: Insights from cardiac disease modeling based on patient-derived iPSCs

This study uses patient-derived iPSCs to model RAF1-associated Noonan syndrome and identifies sarcomere structural abnormalities linked to cardiac dysfunction.

Mitochondrial membrane proteins and VPS35 orchestrate selective removal of mtDNA

The paper identifies a mechanism involving Twinkle, ATAD3, SAMM50, and VPS35 that selectively removes mutant mtDNA through autophagy, offering therapeutic potential for mtDNA diseases and aging.

Size Matters: A Mechanistic Model of Nanoparticle Curvature Effects on Amyloid Fibril Formation

This study investigates how nanoparticle curvature affects amyloid fibril formation of different peptides, finding that smaller nanoparticles inhibit while larger ones accelerate aggregation.

Drought and rewetting events enhance nitrate leaching and seepage-mediated translocation of microbes from beech forest soils

The paper examines how drought and rewetting events affect nitrate leaching and microbial translocation in beech forest soils, finding increased nitrate leaching and shifts in microbial abundance in seepage.

Active integrins regulate white adipose tissue insulin sensitivity and brown fat thermogenesis

This study shows that active integrins regulate white adipose tissue insulin sensitivity and brown fat thermogenesis through interactions with the insulin receptor.

Loss of TP53 mediates suppression of Macrophage Effector Function via Extracellular Vesicles and PDL1 towards Resistance against Chemoimmunotherapy in B-cell malignancies

This paper identifies that TP53 loss in B-cell lymphoma leads to resistance against chemoimmunotherapy by suppressing macrophage effector function through PDL1-expressing extracellular vesicles.

ATM-mediated DNA damage response in macrophages primes phagocytosis and immune checkpoint regulation

The paper shows that DNA damage in macrophages increases PD-L1 expression and phagocytic activity, suggesting a role in chemotherapy response and immune checkpoint regulation.

PAT2 regulates autophagy through vATPase assembly and lysosomal acidification in brown adipocytes

This study shows PAT2 regulates autophagy in brown adipocytes by promoting vATPase assembly and lysosomal acidification in response to amino acid withdrawal.