The natural compound TMYX reduces SAN cells rate by antagonizing the cAMP modulation of f-channels
C. Piantoni, M. Paina, D. Molla, S. Liu, G. Bertoli, H. Jiang, Y. Wang, Y. Wang, Y. Wang, D. DiFrancesco, A. Barbuti, A. Bucchi, M. Baruscotti
The paper shows that TMYX slows pacemaker cell rate by antagonizing cAMP-induced modulation of f-channels, similar to muscarinic stimulation or beta-blockers, but without affecting overall cAMP levels.
bioRxiv · Nov 16, 2021Physiology