Author

A. Bucchi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 3 Paleontology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:electrophysiology· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Assay:imaging· 1 Organism:mouse· 1

Frequent Co-Authors

D. DiFrancesco· 3 shared Y. Wang· 2 shared A. B. Johnsen· 1 shared A. Barbuti· 1 shared A. DSouza· 1 shared A. Moroni· 1 shared A. Porro· 1 shared A. Saponaro· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersPhysiology

D. DiFrancesco

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4 papers

Recent·Most cited

Characterizing the body morphology of the first metacarpal in the Homininae using 3D geometric morphometrics

J. Morley, A. Bucchi, C. Lorenzo, T. A. Püschel

This study uses 3D geometric morphometrics to analyze the shape of the first metacarpal in Homininae species, revealing morphological distinctions and similarities among extant and fossil hominins.

American Journal of Biological Anthropology · Jan 10, 2022Peer-reviewedPaleontology

The natural compound TMYX reduces SAN cells rate by antagonizing the cAMP modulation of f-channels

C. Piantoni, M. Paina, D. Molla, S. Liu, G. Bertoli, H. Jiang, Y. Wang, Y. Wang, Y. Wang, D. DiFrancesco, A. Barbuti, A. Bucchi, M. Baruscotti

The paper shows that TMYX slows pacemaker cell rate by antagonizing cAMP-induced modulation of f-channels, similar to muscarinic stimulation or beta-blockers, but without affecting overall cAMP levels.

bioRxiv · Nov 16, 2021Physiology

Circadian control of intrinsic heart rate via a sinus node clock and the pacemaker channel

Y. Wang, S. Olieslagers, A. B. Johnsen, S. Mastitskaya, H. Ni, Y. Zhang, N. Black, C. Anderson, C. Cox, A. Bucchi, S. Wegner, B. Bano-Otalora, C. Petit, E. Gill, S. J. Logantha, , A. DSouza

The paper shows that the intrinsic heart rate has a circadian rhythm driven by a local clock in the sinus node, regulating Hcn4 expression and funny current.

bioRxiv · Jun 27, 2019Physiology

Structure-guided design of a cell penetrating peptide preventing cAMP modulation of HCN channels

A. Moroni, A. Saponaro, F. Cantini, A. Porro, A. Bucchi, D. DiFrancesco, V. Maione, C. Donadoni, B. Introini, P. Mesirca, M. E. Mangoni, G. Thiel, L. Banci, B. Santoro

The paper designs a cell-penetrating peptide, TRIPnano, that blocks cAMP modulation of HCN channels by competing for binding and inducing allosteric changes, reducing spontaneous action potential firing in sinoatrial node myocytes by 30%.

bioRxiv · Jan 24, 2018Physiology