Application of an integrated computational antibody engineering platform to design SARS-CoV-2 neutralizers
S. Riahi, J. H. Lee, S. Wei, R. Cost, A. Masiero, C. Prades, R. Olfati-Saber, M. Wendt, A. Park, Y. Qiu, Y. Zhou
The paper designs SARS-CoV-2 neutralizing antibodies using a computational platform to improve binding affinity and developability, and introduces trispecific formats and Fc modifications to enhance efficacy and reduce risk.
bioRxiv · Mar 23, 2021Bioengineering