Y. Qiu

The Genome In A Bottle HG002 assembly-based variant benchmark set enables comprehensive benchmarking of small and structural variants.

The paper introduces a comprehensive variant benchmark set derived from a high-quality diploid assembly, improving small and structural variant detection across complex genomic regions.

Genome-wide association study elucidates the genetic architecture of manganese tolerance in Brassica napus

This study identifies genetic loci and genes involved in manganese tolerance in canola using genome-wide association analysis and functional assays.

Have AI-Generated Texts from LLM Infiltrated the Realm of Scientific Writing? A Large-Scale Analysis of Preprint Platforms

This study analyzes AI-generated text infiltration in scientific preprints using LLM detectors, finding widespread use across domains and positive impacts on citation numbers.

Optimized CART Cell Therapy for Metastatic Aggressive Thyroid Cancer

This paper develops a TSHR-targeted CART cell therapy for thyroid cancer and shows that combining it with MAPK inhibitors improves antitumor efficacy in dedifferentiated thyroid cancers.

Double-stranded RNA induces retinal pigment epithelium cell degeneration and inflammation

This study shows dsRNA triggers RIG-I signaling, leading to inflammation and RPE degeneration in AMD, with implications for pathogenesis.

Contractile to extensile transitions and mechanical adaptability enabled by activity in cytoskeletal structures

This study shows how motor activity enables cytoskeletal structures to adapt mechanically, transforming from contractile to extensile states under tension.

Inhibition of MMP 2 protects the endothelial glycocalyx and improves diastolic function in diabetic cardiomyopathy

This study shows that inhibiting MMP2/9 protects the endothelial glycocalyx and improves diastolic function in diabetic cardiomyopathy.

Small molecule inhibitor binds to NLRP3 and prevents inflammasome activation

The paper identifies that NLRP3 binds and cleaves oxidized DNA, and small molecule drugs inhibit this process to prevent inflammasome activation.

NS2B-D55E and NS2B-E65D Variations are Responsible for Differences in NS2B-NS3 Protease Activities Between Japanese Encephalitis Virus Genotype I and III in Fluorogenic Peptide Model

This study identifies NS2B-55 and NS2B-65 variations as responsible for differences in NS2B-NS3 protease activity between JEV genotype I and III using fluorogenic peptide assays.

FITM2 deficiency results in ER lipid accumulation, ER stress, reduced apolipoprotein B lipidation, and VLDL triglyceride secretion in vitro and in mouse liver

This study shows FITM2 deficiency reduces VLDL triglyceride secretion and causes ER stress and lipid accumulation in liver cells and mice.

Climate warming suppresses soil abundant fungal taxa and reduces soil carbon efflux in a semi-arid grassland

This study shows that warming reduces fungal abundance and shifts fungal community composition in semi-arid grasslands, leading to reduced soil carbon efflux.

Rhythmic lipid and gene expression responses to chilling in panicoid grasses

The paper examines gene expression and lipid changes in three panicoid grasses under chilling stress, revealing conserved and species-specific responses and identifying potential target genes for improving chilling tolerance.

Structural insights into abscisic acid exporter AtABCG25

The paper determines the structure of AtABCG25, an ABA exporter, revealing its mechanism of ABA binding and transport through cryo-EM.

Global and local adaptation to aridity in a desert plant Gymnocarpos przewalskii

This study identifies genes involved in global and local adaptation to aridity in Gymnocarpos przewalskii, finding limited overlap between the two processes.

The molecular basis of parental conflict driven regulation of endosperm cellularization

The paper identifies maternally expressed auxin response factors that promote endosperm cellularization and regulate seed size, revealing antagonistic parental control over this process.

Hypoxia-induced circSTT3A maintains Breast Cancer Stem Cell formation by Stabilizing PGK1 protein

This study identifies circSTT3A as a hypoxia-induced circular RNA that stabilizes PGK1 protein to promote breast cancer stem cell formation and chemotherapy resistance.

A MAP kinase cascade broadly regulates development and virulence of Sclerotinia sclerotiorum and can be targeted by HIGS for disease control

This study identifies a conserved MAPK cascade in S. sclerotiorum essential for growth, development, and virulence, and demonstrates its targeting by HIGS reduces pathogen virulence.

Single fluorogen imaging reveals distinct environmental and structural features of biomolecular condensates

This study uses single-fluorogen imaging to reveal that biomolecular condensates have hydrophobic internal environments and spatially inhomogeneous molecular organization.

Structure of human NaV1.6 channel reveals Na+ selectivity and pore blockade by 4,9-anhydro-tetrodotoxin

The paper presents cryo-EM structures of human NaV1.6 channels with and without 4,9-anhydro-tetrodotoxin, revealing Na+ selectivity and inhibition mechanisms.

Updated phylogeny and protein structure predictions revise the hypothesis on the origin of MADS-box transcription factors in land plants

The paper revises the origin of MADS-box TFs in land plants by showing Type I and II genes arose from MEF2-type genes through duplication in the land plant ancestor, supported by protein structure predictions.

Leafhopper transmits soybean stay-green associated virus to legume plants

This study identifies leafhoppers as vectors for SoSGV, a virus associated with soybean stay-green syndrome, and shows they can transmit the virus to legume plants.

Molecular insights into the gating mechanisms of voltage-gated calcium channel CaV2.3

This study determines the cryo-EM structure of human CaV2.3 channels and identifies key residues and interactions involved in channel gating and inactivation.

Skeletal muscle lineage is dispensable for appendage regeneration in axolotl

This study shows that skeletal muscle is not required for limb regeneration in axolotls, as Pax7 mutants regenerate limbs with normal patterns and cell composition.

Reduced Neutralization of SARS-CoV-2 Omicron Variant in Sera from SARS-CoV-1 Survivors after 3-dose of Vaccination

This study shows that SARS-CoV-1 survivors vaccinated with ZF2001 have reduced neutralization against SARS-CoV-2 Omicron compared to other variants.

Key mutations on spike protein altering ACE2 receptor utilization and potentially expanding host range of emerging SARS-CoV-2 variants

This study identifies key spike protein mutations in SARS-CoV-2 variants that enhance ACE2 receptor utilization across multiple animal species, potentially increasing host range and spillover risk.

Exosomally targeting microRNA23a ameliorates microvascular endothelial barrier dysfunction following rickettsial infection

This study shows that exosomal miR23a from rickettsial-infected endothelial cells disrupts BMEC barrier function by targeting ZO-1, and that anti-miR23a exosomes can restore barrier integrity.

Neuronal glucose metabolism sets cholinergic tone and controls thermo-regulated signaling at the neuromuscular junction

This study shows that increasing glycolysis in cholinergic neurons boosts acetylcholine levels, reduces blood pressure and heart rate, and improves cold resistance.

PIF4/HEMERA-mediated daytime thermosensory growth requires the Mediator subunit MED14

The Mediator subunit MED14 promotes thermomorphogenesis by interacting with PIF4 and HEMERA to induce the expression of growth-promoting genes at elevated temperatures.

Comparative miRNA Transcriptomics of Mouse and Macaque Reveals MYOC is An Inhibitor for C. neoformans Invasion into Brain

Novel plasma exosome biomarkers for prostate cancer progression in co-morbid metabolic disease

This study identifies plasma exosomal miRNAs associated with T2D that induce EMT and immune checkpoint expression in prostate cancer cells.