C. R. King

The paper characterizes human antibodies against PfRH5, identifies key features of potent inhibitors, and demonstrates their prophylactic potential against malaria.

This paper develops a stabilized RH5 VLP vaccine that induces improved anti-malarial antibodies compared to a soluble protein vaccine in preclinical studies.

The paper identifies human antibodies targeting Plasmodium falciparum sexual stages, revealing cross-stage recognition of glutamate-rich repeats through a novel method.

The paper uses a CRISPR screen to identify TREX1 as a pro-viral host factor that modulates DNA sensing during influenza infection.

The paper analyzes structural and functional properties of antibodies targeting PfCSP, showing how homotypic interactions and affinity maturation influence protection against malaria.

The paper identifies a lipid trafficking pathway between yeast vacuoles and mitochondria that enhances mitochondrial activity and cell lifespan under glucose starvation.

The paper analyzes eight anti-NANP antibodies from a malaria vaccine trial, linking their structural and biophysical properties to in vivo protection against P. falciparum.

The paper presents a cryo-EM structure of Plasmodium falciparum CSP with vaccine-elicited antibodies, revealing a spiral conformation stabilized by inter-antibody contacts.