I. A. Wilson

This study uses deep mutational scanning to analyze the SARS-CoV-2 spike fusion peptide, identifying mutations affecting viral entry and antibody resistance.

This study reports the structures and mechanistic insights of PLD3 and PLD4, revealing their exonuclease activity, phosphatase function, and disease relevance.

This study identifies broadly neutralizing monoclonal and bispecific antibodies from a Gamma variant-infected individual that effectively neutralize multiple SARS-CoV-2 variants.

The paper introduces a triple tandem trimer (TTT) design for HIV-1 Env and influenza HA immunogens, showing improved trimer-specific immune responses in viral vectored vaccines.

This paper isolates and characterizes Affimers, antibody-like proteins, that inhibit influenza A virus H3 subtype infection in vitro and block HA-receptor interactions.

This paper develops a human antibody fragment that reverses carfentanil-induced respiratory depression by targeting multiple opioid analogs.

This study shows that IGV allelic polymorphisms widely affect antibody reactivity by analyzing antibody-antigen structures and experimental data.

This study uses multi-scale simulations to predict phospholipid complexes and membrane association of HIV-1 MPER antibodies, showing lipid interactions stabilize antibody binding and correlate with neutralization potency.

The paper identifies broadly neutralizing antibodies against SARS-CoV-2 that target conserved regions on the spike RBD, showing resistance to antigenic drift and suggesting potential vaccine targets.

This paper identifies a broadly neutralizing antibody against SARS-CoV-2 that targets the receptor-binding site and remains effective against multiple Omicron subvariants.

The paper determines the cryo-EM structure of the anti-PfCSP antibody L9, revealing its multivalent binding to NPNV repeats and the role of the light chain in affinity and protective efficacy.

The paper identifies mutations that stabilize the prefusion conformation of SARS-CoV-2 spike while improving expression, using a combination of fluorescence-based assays, cell display, and deep mutational scanning.

The paper analyzes structural and functional properties of antibodies targeting PfCSP, showing how homotypic interactions and affinity maturation influence protection against malaria.

This study uses mesoscale simulations to analyze the dynamics of influenza glycoproteins, revealing new antigenic states and a vulnerability site in neuraminidase.

Glycan trimming of HIV-1 Env immunogens improves vaccine-induced neutralizing antibody responses in small animals and primates.

This study shows that HIV infection shifts the SARS-CoV-2 B cell response toward an extrafollicular pathway, leading to lower affinity antibodies and reduced vaccine efficacy in people living with HIV.

The paper identifies a public antibody response that cross-neutralizes all SARS-CoV-2 variants, including Omicron, by analyzing published data on germline gene combinations and molecular features.

The paper evaluates the potency of mAb J08 against SARS-CoV-2 variants using cell-based assays and cryo-EM, showing its resistance to escape mutations and broad binding capability.

The paper identifies six monoclonal antibodies that broadly neutralize coronaviruses by targeting the conserved fusion peptide.

This paper develops aminoadamantane nitrate compounds that inhibit SARS-CoV-2 infection by S-nitrosylating ACE2 and blocking viral entry, showing efficacy in vitro and in a Syrian hamster model.

The paper identifies a broadly neutralizing epitope in SARS-related coronaviruses that is effective against variants, including Omicron, and suggests its use for universal vaccine design.

The paper identifies broadly neutralizing antibodies targeting the S2 region of betacoronavirus spikes that protect against SARS-CoV-1, SARS-CoV-2, and MERS-CoV.

The paper isolates and characterizes ultrahigh-affinity nanobodies from a camelid immunized with SARS-CoV-2 RBD, showing broad sarbecovirus neutralization and structural insights.

The paper identifies a YYDRxG motif in antibodies that broadly neutralize SARS-CoV-2 variants and related viruses, suggesting a conserved epitope targeting strategy.

The paper analyzes 8,000 SARS-CoV-2 spike-targeting antibodies from 200 donors to identify common molecular features and demonstrates a deep learning model for predicting antigen specificity.

SARS-CoV-2 Beta variant infection generates lineage-specific antibodies and cross-reactive antibodies with neutralizing activity against wild-type and other variants.

This study isolates a panel of broadly neutralizing antibodies against SARS-like viruses from donors, showing effectiveness against multiple variants including Omicron.

This study shows that rhesus macaques can be immunized to produce broadly neutralizing antibodies against multiple SARS-related viruses, highlighting differences in B cell repertoires between humans and macaques.

This study uses single particle mass analyses to examine antibody binding to the SARS-CoV-2 spike protein, revealing sub-stoichiometric binding and its effectiveness in blocking ACE2.

This paper describes engineering a SARS-CoV-1 neutralizing antibody to effectively neutralize SARS-CoV-2 through directed evolution and affinity maturation.