T. Pholcharee

An Engineered Human-Antibody Fragment with Fentanyl Pan-Specificity that Reverses Carfentanil-Induced Respiratory Depression

This paper develops a human antibody fragment that reverses carfentanil-induced respiratory depression by targeting multiple opioid analogs.

Structural basis for DARC binding in reticulocyte invasion by Plasmodium vivax

The paper determines the structure of PvDBP-RII bound to sulphated DARC peptide, identifies a critical sulphate interaction, and reveals an epitope for a growth-inhibitory antibody.

Structural basis of epitope selectivity and potent protection from malaria by PfCSP antibody L9

The paper determines the cryo-EM structure of the anti-PfCSP antibody L9, revealing its multivalent binding to NPNV repeats and the role of the light chain in affinity and protective efficacy.

Affinity-matured homotypic interactions induce spectrum of PfCSP-antibody structures that influence protection from malaria infection

The paper analyzes structural and functional properties of antibodies targeting PfCSP, showing how homotypic interactions and affinity maturation influence protection against malaria.

Structural and biophysical correlation of anti-NANP antibodies with in vivo protection against P. falciparum

The paper analyzes eight anti-NANP antibodies from a malaria vaccine trial, linking their structural and biophysical properties to in vivo protection against P. falciparum.

A high-affinity antibody against the CSP N-terminal domain lacks Plasmodium falciparum inhibitory activity

This study characterizes a monoclonal antibody against the N-terminal domain of PfCSP, finding it has high affinity but lacks functional inhibitory activity against sporozoites.