A. Mehle

Cryptic proteins translated from deletion-containing viral genomes dramatically expand the influenza virus proteome

The paper identifies cryptic proteins from deletion-containing viral genomes that inhibit influenza virus replication and expand its proteome.

Pathogen-driven CRISPR screens identify TREX1 as a regulator of DNA self-sensing during influenza virus infection

The paper uses a CRISPR screen to identify TREX1 as a pro-viral host factor that modulates DNA sensing during influenza infection.

Influenza A virus undergoes compartmentalized replication in vivo dominated by stochastic bottlenecks

This study tracks influenza A virus diversity in ferrets, showing compartmentalized replication and stochastic bottlenecks shaping genetic diversity within lung lobes.

Alternative splicing liberates a cryptic cytoplasmic isoform of mitochondrial MECR that antagonizes influenza virus

The paper identifies a cryptic cytoplasmic isoform of MECR generated by alternative splicing that inhibits influenza virus replication by blocking viral RNP assembly.

Phosphorylation controls RNA binding and transcription by the influenza virus polymerase

This study identifies phosphorylation sites in the influenza virus polymerase that regulate its activity and virus replication by affecting RNA binding and transcription.

EPS8 facilitates uncoating of influenza A virus

This study identifies EPS8 as a host factor that facilitates influenza A virus uncoating by delaying nuclear import of ribonucleoprotein complexes.

Differential splicing of ANP32A in birds alters its ability to stimulate RNA synthesis by restricted influenza polymerase

The paper shows that differential splicing of ANP32A in birds affects its ability to stimulate RNA synthesis by influenza polymerase, influencing viral replication and host range.

Photocatalytic disinfection of surfaces with copper doped TiO2 nanotube coatings illuminated by ceiling mounted fluorescent lights

The paper demonstrates that copper-doped TiO2 nanotube coatings on surfaces, when illuminated by fluorescent lights, effectively disinfect surfaces by reducing Listeria innocua growth by 99%.