Regulatory T Cell-like Response to SARS-CoV-2 in Jamaican Fruit Bats Transduced with Human ACE2
B. Burke, S. Rocha, S. Zhan, M. Eckley, C. Reasoner, A. Addetia, J. Lewis, A. C. Fagre, P. Charley, J. A. Richt, S. R. Weiss, R. Tjalkens, D. Veesler, T. Aboellail, T. Schountz
This study shows Jamaican fruit bats are poorly susceptible to SARS-CoV-2 but develop a regulatory T cell-like immune response when transduced with human ACE2, leading to lung infection without overt disease.
bioRxiv · Feb 13, 2023Microbiology