J. Lewis

Co-circulation of distinct high pathogenicity avian influenza virus (HPAIV) subtypes in a mass mortality event in wild seabirds and co-location with dead seals

The paper reports the co-circulation of H5N1 and H5N5 HPAIV subtypes in a mass mortality event involving seabirds and seals in Great Britain, with the first recorded instance of two subtypes co-occurring in the same avian population and the first H5N5 detection in mammals in GB.

Gemcitabine and ATR inhibitors synergize to kill PDAC cells by blocking DNA damage response

This study identifies ATR inhibitors as synergistic with gemcitabine in killing PDAC cells by blocking the DNA damage response pathway.

A murky ruling threatens the fate of millions of US wetlands

The paper estimates that 22-36% of US wetlands could lose federal protections under the Clean Water Act due to the Sackett v. EPA ruling, with the Midwest and Northeast at highest risk.

Regulatory T Cell-like Response to SARS-CoV-2 in Jamaican Fruit Bats Transduced with Human ACE2

This study shows Jamaican fruit bats are poorly susceptible to SARS-CoV-2 but develop a regulatory T cell-like immune response when transduced with human ACE2, leading to lung infection without overt disease.

SARS-CoV-2 infects multiple species of North American deer mice and causes clinical disease in the California mouse

This study shows SARS-CoV-2 infects multiple North American deer mice and causes clinical disease in California mice, suggesting potential wildlife reservoirs and co-morbidity factors for severe COVID-19.

The ExtRA Capacity Test: Reliability and validity study of a new tool for assessing shoulder muscle performance

The paper evaluates the reliability and validity of the ExtRA Capacity Test for assessing shoulder muscle performance, finding it reliable for abduction but less valid for external rotation.

Structural basis for tunable affinity and specificity of LxCxEdependentprotein interactions with the retinoblastoma protein family

This study presents crystal structures of the p107 pocket domain bound to LxCxE peptides, revealing structural determinants that explain differences in binding affinity between viral and cellular proteins.

Preferential associations of soil fungal taxa under mixed compositions of eastern American tree species

The paper examines soil fungal communities under different tree species and their combinations, finding preferential associations and functional differences.

Soil fungal communities vary more with soil characteristics than tree diversity at a local scale

The paper examines how soil fungal communities and enzymatic activity are influenced by soil characteristics and plant identity in a mixed-hardwood woodland.

Priority effects among amphibian microbes lead to varying levels of Bd infection

The paper shows priority effects among amphibian microbes can influence Bd infection levels, with interactions being complex and community composition-dependent.

A synergistic interaction between HDAC- and PARP inhibitors in childhood tumors with chromothripsis

The paper identifies a synergistic effect between HDAC and PARP inhibitors in childhood tumors with chromothripsis, validated through drug screening and in vivo models.

A novel glucocorticoid and androgen receptor modulator reduces viral entry and innate immune inflammatory responses in the Syrian Hamster model of SARS-CoV-2

This paper shows that PT150, a glucocorticoid and androgen receptor antagonist, reduces SARS-CoV-2 replication and inflammatory responses in Syrian hamsters.

The DAXX-SREBP axis promotes oncogenic lipogenesis and tumorigenesis

This study identifies the DAXX-SREBP axis as a driver of lipogenesis and tumorigenesis by showing its role in activating lipogenic gene expression and promoting tumor growth.

A potent SARS-CoV-2 neutralizing human monoclonal antibody that reduces viral burden and disease severity in Syrian hamsters

SARS-CoV-2 infection, neuropathogenesis and transmission among deer mice: Implications for reverse zoonosis to New World rodents

This study infects deer mice with SARS-CoV-2, showing robust replication and potential for natural transmission, with a new spike protein mutation emerging during in vivo passage.

Evaluation of a novel multiplexed assay for determining IgG levels and functional activity to SARS-CoV-2.

This study evaluates a multiplexed assay for detecting IgG levels and functional activity against SARS-CoV-2 antigens, finding high sensitivity and specificity for S, RBD, and N antigens.

Improving the accessibility and transferability of machine learning algorithms for identification of animals in camera trap images: MLWIC2

This paper develops two deep learning models for camera trap image classification, achieving high accuracy and transferability across locations, and provides an accessible R package for biologists.

Structure-function analysis of ZAR1 immune receptor reveals key molecular interactions for activity

Structure-informed analyses reveal multiple finely-tuned intramolecular interactions that regulate the activity of the immune receptor ZAR1.