S. Rocha

Endothelial gain of PIEZO/TRPV mechanosensors drives cavernous malformations

This study identifies PIEZO1, TRPV2, and TRPV4 as mechanosensors overexpressed in CCM lesions, showing their role in driving disease through altered adhesion and matrix degradation.

Biocompatible Neodymium-Doped Nanocrystals as Probes for Diffraction-limited, in vitro Temperature Sensing

This paper develops neodymium-doped nanocrystals for diffraction-limited, in vitro temperature sensing with high sensitivity and biocompatibility in cancer cells.

Systematic characterization of site-specific proline hydroxylation using hydrophilic interaction chromatography and mass spectrometry

This paper develops a workflow to identify proline hydroxylation sites using HILIC and LC-MS, finding 4,993 and 3,247 sites in HEK293 and RCC4 cells, respectively.

tRNASer overexpression induces adaptive mutations in NSCLC tumors

This study shows that overexpressing tRNASer in NSCLC tumors increases mutation burden and generates variants that promote proliferation and therapy resistance.

Regulatory T Cell-like Response to SARS-CoV-2 in Jamaican Fruit Bats Transduced with Human ACE2

This study shows Jamaican fruit bats are poorly susceptible to SARS-CoV-2 but develop a regulatory T cell-like immune response when transduced with human ACE2, leading to lung infection without overt disease.

Flat clathrin lattices are linked to metastatic potential in colorectal cancer

The paper shows that flat clathrin lattices are more prevalent in colorectal cancer cells with higher metastatic potential.

Disruption of HIF1A translational control attenuates the HIF-dependent hypoxic response and solid tumour formation in vivo

This study shows that disrupting HIF1A translational control reduces hypoxic response and solid tumour formation in mice.

Endosomal removal and disposal of dysfunctional, immunostimulatory mitochondrial DNA

The paper investigates how dysfunctional mitochondrial DNA is removed via an endosomal pathway, showing that defects in mtDNA replication and segregation trigger a fission checkpoint leading to immune activation and eventual disposal through RAB7-containing endosomes.

Synthetic fibrous hydrogels as a platform to decipher cell-matrix mechanical interactions

This study uses synthetic fibrous hydrogels to investigate cell-matrix mechanical interactions and their impact on cellular behavior.

The evolution of two transmissible leukaemias colonizing the coasts of Europe

This study investigates the origin and evolution of two transmissible leukaemias in common cockles, identifying clonal origins, mutational signatures, and genomic instability.

Transcriptome landscape of kleptoplastic sea slug Elysia viridis

This study reports the transcriptome of the kleptoplastic sea slug Elysia viridis, identifying genes related to stress response and ROS quenching, and functional annotations for a large portion of its protein-coding sequences.

Rapid stem cell spreading induced by high affinity α5β1 integrin-selective bicyclic RGD peptide in biomimetic hydrogels

This study presents a synthetic ECM with high-affinity integrin-selective peptides that promote rapid stem cell spreading compared to traditional RGD or Matrigel controls.

Epithelial-mesenchymal plasticity induced by discontinuous exposure to TGFβ1 promotes tumour growth

The paper shows that discontinuous TGFβ1 exposure induces EMT/MET transitions in EpH4 cells, leading to RE-cells with molecular and functional heterogeneity that promotes tumour growth.

Versatile and Robust Method for Antibody Conjugation to Nanoparticles with High Targeting Efficiency

This paper develops a method for antibody conjugation to nanoparticles using click chemistry, showing high targeting efficiency and reproducibility for CD44 and EGFR markers.

VHL inhibitor binding increases intracellular level of VHL

This study shows VHL inhibitors increase intracellular VHL levels through protein stabilization, leading to reduced HIF-1 protein and selective HIF activation.

Glycine receptor α3K governs mobility and conductance of L/K splice variant heteropentamers

This study functionally characterizes GlyR-3 splice variant heteropentamerization using fluorescence microscopy and electrophysiology, showing they adopt the mobility of the K variant and exhibit conductance similar to 3K.

Filamentation in Candida albicans is modulated by adaptive translation of farnesol signalling genes

This study shows that atypical CUG codon translation in Candida albicans modulates filamentation by altering farnesol production and Nrg1 repressor degradation.

Hypoxia induces rapid changes to histone methylation reprogramming chromatin for the cellular response

The paper shows hypoxia causes rapid, HIF-independent changes in histone methylation marks, linking oxygen sensing to chromatin reprogramming for cellular response.