C. Reding

Improving Nitrofurantoin Resistance Prediction in Escherichia coli from Whole Genome Sequence by Integrating NfsA/B Enzyme Assays

The paper identifies specific amino acid substitutions in NfsA and NfsB that reduce enzyme activity and cause nitrofurantoin resistance in E. coli, but finds that WGS alone cannot reliably predict resistance due to functional silent mutations and downregulated gene expression.

Harvesting and amplifying gene cassettes confers cross-resistance to critically important antibiotics

The paper shows that gene cassettes in an integron, amplified by IS26, confer resistance to amikacin and piperacillin/tazobactam, often leaving meropenem as the last-resort antibiotic.

Genomic epidemiology of third-generation cephalosporin-resistant Escherichia coli from Argentinian pig and dairy farms reveals animal-specific patterns of co-resistance and resistance mechanisms

This study identifies animal-specific patterns of third-generation cephalosporin resistance in E. coli from Argentinian pig and dairy farms, revealing differences in resistance mechanisms and co-resistance patterns.

Predicting the re-distribution of antibiotic molecules caused byinter-species interactions in microbial communities

The paper shows that inter-species interactions in microbial communities redistribute antibiotic molecules, affecting drug efficacy differently than in single-species assays.

Clinical Antibiotic Resistance Patterns Across 70 Countries

The paper analyzes global antibiotic resistance patterns using clinical data from 70 countries, identifying resistance dynamics and proposing a phase plane method to detect resistance risk.