Disrupted structure and aberrant function of CHIP mediates the loss of motor and cognitive function in preclinical models of cerebellar CHIPopathy
C.-h. Shi, C. Rubel, S. E. Soss, R. Sanchez-Hodge, S. Zhang, D. A. Stevens, H. McDonough, R. C. Page, W. Chazin, C. Patterson, C.-y. Mao, M. S. Willis, H.-Y. Luo, M.-b. Tang, P. Du, , J. Schisler
This study investigates the effects of a CHIP mutation in preclinical models, showing it causes structural disruption and functional loss linked to motor and cognitive deficits.
bioRxiv · Mar 15, 2018Animal Behavior & Cognition