P. Du

EigenBrain maps cortical molecular architecture from functional, geometric, and structural eigenmodes

The paper shows functional MRI eigenmodes can approximate specific receptor and transporter distributions in the cortex, while structural and geometric eigenmodes cannot, and applies this to detect molecular differences in autism and schizophrenia.

New role of cardiomyocyte Bmal1 in the regulation of sex-specific heart transcriptomes

This study shows that cardiomyocyte Bmal1 is essential for sex-specific gene expression in the adult mouse heart, as its loss reduces sex differences in circadian transcriptomes.

Temporal genomic analysis of melanoma rejection identifies regulators of tumor immune evasion

The paper identifies Mif as a regulator of tumor immune evasion in low intra-tumor heterogeneity melanoma by analyzing single-cell RNA sequencing data and validating in patient data.

Rationally designed multimeric nanovaccines using icosahedral DNA origami for molecularly controlled display of SARS-CoV-2 receptor binding domain

This study designs multimeric nanovaccines using icosahedral DNA origami to display SARS-CoV-2 RBD, showing enhanced B cell activation and immune responses in mice.

Aβ-aggregation-generated blue autofluorescence illuminates senile plaques, complex blood and vascular pathologies in the Alzheimer's disease

Surface-based Characterization of Gastric Anatomy and Motility using Magnetic Resonance Imaging and Neural Ordinary Differential Equation

This paper introduces a method using MRI and neural ODEs to model gastric motility and anatomy in rats, revealing functional regions and muscle activity patterns.

Validation of non-invasive body-surface gastric mapping for detecting electrophysiological biomarkers by simultaneous high-resolution serosal mapping in a porcine model

This study validates body-surface gastric mapping as a reliable non-invasive method for detecting gastric slow wave frequency and propagation direction using simultaneous serosal recordings in a porcine model.

The Skeletal Muscle Circadian Clock Regulates Titin Splicing Through RBM20

This study shows that the skeletal muscle circadian clock regulates titin splicing via RBM20, affecting sarcomere length and function.

Genomic inference of a human super bottleneck in Mid-Pleistocene transition

The paper infers a population super bottleneck in African humans around 930-813 thousand years ago using genomic data and the FitCoal method.

CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 variants

This study shows that CD147 antibody inhibits SARS-CoV-2 infection and cytokine storm in variants by blocking viral entry and reducing inflammatory responses.

Species Tree Inference on Data with Paralogs is Accurate Using Methods Intended to Deal with Incomplete Lineage Sorting

This study shows that species tree inference methods can accurately handle data with paralogs, even when incomplete lineage sorting is present.

SARS-CoV-2 manipulates the SR-B1-mediated HDL uptake pathway for its entry

This study shows SARS-CoV-2 uses the SR-B1-mediated HDL uptake pathway alongside ACE2 for entry, and blocking this pathway inhibits infection.

Senile plaques in Alzheimer's disease arise from Aβ and Cathepsin D-enriched amyloidogenic mixtures out of intravascular hemolysis and Charcot-Bouchard aneurysm-related vascular degeneration

This study identifies that senile plaques in Alzheimer's disease originate from Aβ and Cathepsin D-enriched amyloid mixtures formed through intravascular hemolysis and vascular degeneration.

Broad and differential animal ACE2 receptor usage by SARS-CoV-2

This study examines ACE2 receptor usage by SARS-CoV-2 across 14 mammalian species, finding broad receptor activity and implications for zoonotic transmission and animal models.

SARS-CoV-2 invades host cells via a novel route: CD147-spike protein

This study identifies CD147 as a novel receptor for SARS-CoV-2 spike protein, showing that Meplazumab inhibits viral entry with EC50 24.86 g/mL and confirms the interaction through binding assays and microscopy.

Metabolic wastes are extracellularly disposed by excretosomes, nanotubes and exophers in mouse HT22 cells through an autophagic vesicle clustering mechanism

This study identifies excretosomes and exophers as mechanisms for metabolic waste disposal in HT22 cells, showing their role in stress response and neurodegenerative disease pathology.

Functional classification of noncoding RNAs associated with distinct histone modifications by PIRCh-seq

The paper introduces PIRCh-seq to profile chromatin-associated RNAs with histone modifications, identifying functional groups of lncRNAs and allele-specific interactions.

Unifying Gene Duplication, Loss, and Coalescence on Phylogenetic Networks

This paper introduces a unified model for gene evolution incorporating ILS, GDL, and introgression, and develops an algorithm to estimate phylogenetic network parameters.

Sublethal β-lactam antibiotics induce PhpP phosphatase expression and StkP kinase phosphorylation in PBP-independent β-lactam antibiotic resistance of Streptococcus pneumoniae

Disrupted structure and aberrant function of CHIP mediates the loss of motor and cognitive function in preclinical models of cerebellar CHIPopathy

This study investigates the effects of a CHIP mutation in preclinical models, showing it causes structural disruption and functional loss linked to motor and cognitive deficits.