PhysiologybioRxiv
Cardiomyocyte Contractile Impairment in Heart Failure Results from Reduced BAG3-mediated Sarcomeric Protein Turnover
T. G. Martin, V. D. Myers, P. Dubey…·J. A. Kirk
The paper shows reduced BAG3-mediated sarcomere turnover causes cardiomyocyte contractile impairment in heart failure, with gene therapy restoring function in mice.