BiochemistrybioRxiv
Structural basis of the mechanism and inhibition of a human ceramide synthase
T. C. Pascoa, A. C. W. Pike, C. S. Tautermann…·D. B. Sauer
This study determines the structural mechanism of CerS6, a ceramide synthase, using cryo-EM and biochemical analysis, revealing a ping-pong reaction mechanism and insights into fumonisin B1 inhibition.
DOI 10.1038/s41594-024-01414-3