Author

C. S. Wylie

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Approach:statistical model· 1 Organism:yeast· 1

Frequent Co-Authors

D. M. Weinreich· 2 shared B. M. Rubenstein· 1 shared F. M. Ytreberg· 1 shared J. Huang· 1 shared J. S. Patel· 1 shared J. Yang· 1 shared M. T. Naik· 1 shared N. Naik· 1 shared

Activity by Year

2017-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBiophysics

D. M. Weinreich

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2 papers

Recent·Most cited

BiophysicsbioRxivApr 15, 2020

Predicting the Viability of Beta-Lactamase: How Folding and Binding Free Energies Correlate with Beta-Lactamase Fitness

J. Yang, N. Naik, J. S. Patel…·B. M. Rubenstein

This paper evaluates how well thermodynamic folding and binding free energies predict the fitness of beta-lactamase mutants using experimental data and computational models.

DOI 10.1371/journal.pone.0233509

protein structurestatistical model

𝕏 PostBluesky

Evolutionary BiologybioRxivJun 28, 2017

Sign of selection on mutation rate modifiers depends on population size

Y. Raynes, C. S. Wylie, P. D. Sniegowski, D. M. Weinreich

The paper shows that mutator alleles, which increase mutation rates, are favored by indirect selection in large populations but disfavored in smaller ones, demonstrating sign inversion in their selective effect.

DOI 10.1073/pnas.1715996115

yeastexperimental assay

𝕏 PostBluesky