BiochemistrybioRxiv
Rational optimization of a transcription factor activation domain inhibitor
S. Basu, P. Martinez-Cristobal, M. Pesarrodona…·X. Salvatella
This study optimizes a small molecule inhibitor targeting the aromatic-rich activation domain of the androgen receptor, showing improved affinity and antitumorigenic effects in prostate cancer models.
DOI 10.1038/s41594-023-01159-5