Author

C. Shembrey

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Organism:human· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. G. Heriot· 2 shared C. Behrenbruch· 2 shared F. Hollande· 2 shared M. Foroutan· 2 shared A. H. Wei· 1 shared A. Newbold· 1 shared A. Puisieux· 1 shared A.-M. Patch· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCancer Biology

A. G. Heriot

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Author profile →

3 papers

Recent·Most cited

A new highly-specific Natural Killer cell-specific gene signature predicting recurrence in colorectal cancer patients.

C. Shembrey, C. Behrenbruch, B. P. Loveday, A. G. Heriot, M. Foroutan, F. Hollande

This paper develops a CRC-specific NK cell gene signature that predicts recurrence in colorectal cancer patients by identifying high NK cell activity associated with improved survival.

bioRxiv · Apr 29, 2022Cancer Biology

Targeting of TP53-independent cell cycle checkpoints overcomes FOLFOX resistance in Metastatic Colorectal Cancer

C. Behrenbruch, M. Foroutan, P. Lind, J. Smith, M. Grandin, B. Cooper, C. Shembrey, S. Ramm, K. Cowley, I. Nikolic, J. Liuu, J. Cursons, R. Millen, A.-M. Patch, N. D. Huntington, , F. Hollande

This study identifies FOLFOX resistance in metastatic CRC through cell cycle checkpoint dysregulation and shows that targeting these checkpoints can resensitize resistant organoids to FOLFOX.

bioRxiv · Feb 4, 2021 · PreprintCancer Biology

Reprogramming of serine metabolism is an actionable vulnerability in FLT3-ITD driven acute myeloid leukaemia

S. Bjelosevic, E. Gruber, A. Newbold, L. M. Kats, C. Shembrey, T. C. Abrehart, I. Todorovski, G. Pomilio, A. H. Wei, G. P. Gregory, S. J. Vervoort, K. K. Brown, R. W. Johnstone

This study identifies serine metabolism as a vulnerability in FLT3-ITD AML, showing that targeting serine synthesis enhances chemotherapy efficacy.

Cancer Discovery · Jan 12, 2021Peer-reviewedCancer Biology