Author

C. Behrenbruch

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Organism:human· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

M. Foroutan· 3 shared A. G. Heriot· 2 shared C. Shembrey· 2 shared F. Hollande· 2 shared J. Cursons· 2 shared N. D. Huntington· 2 shared A. Kallies· 1 shared A. Pfefferle· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersCancer Biology

M. Foroutan

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3 papers

Recent·Most cited

A new highly-specific Natural Killer cell-specific gene signature predicting recurrence in colorectal cancer patients.

C. Shembrey, C. Behrenbruch, B. P. Loveday, A. G. Heriot, M. Foroutan, F. Hollande

This paper develops a CRC-specific NK cell gene signature that predicts recurrence in colorectal cancer patients by identifying high NK cell activity associated with improved survival.

bioRxiv · Apr 29, 2022Cancer Biology

Targeting of TP53-independent cell cycle checkpoints overcomes FOLFOX resistance in Metastatic Colorectal Cancer

C. Behrenbruch, M. Foroutan, P. Lind, J. Smith, M. Grandin, B. Cooper, C. Shembrey, S. Ramm, K. Cowley, I. Nikolic, J. Liuu, J. Cursons, R. Millen, A.-M. Patch, N. D. Huntington, , F. Hollande

This study identifies FOLFOX resistance in metastatic CRC through cell cycle checkpoint dysregulation and shows that targeting these checkpoints can resensitize resistant organoids to FOLFOX.

bioRxiv · Feb 4, 2021 · PreprintCancer Biology

The ratio of exhausted to resident infiltrating lymphocytes is prognostic for colorectal cancer patient outcome

M. Foroutan, R. Molania, A. Pfefferle, C. Behrenbruch, A. Kallies, T. P. Speed, J. Cursons, N. D. Huntington

This study identifies signatures of lymphocyte residency and exhaustion in colorectal cancer using single-cell RNA-seq and shows their association with patient survival outcomes.

bioRxiv · Dec 19, 2020Cancer Biology