I. Nikolic

Lack of p38 activation in T cells increases IL-35 production and protects against obesity by promoting thermogenesis

This study shows that inhibiting p38 in T cells increases IL-35 production, which enhances thermogenesis and protects against obesity.

Repertoire and abundance of secreted virulence factors shape the pathogenic capacity of Pseudomonas syringae pv. aptata

This study identifies strain-specific secretome features in Pseudomonas syringae pv. aptata that correlate with pathogenicity.

Targeting of TP53-independent cell cycle checkpoints overcomes FOLFOX resistance in Metastatic Colorectal Cancer

This study identifies FOLFOX resistance in metastatic CRC through cell cycle checkpoint dysregulation and shows that targeting these checkpoints can resensitize resistant organoids to FOLFOX.

Genome-wide CRISPR screens reveal APR-246 (Eprenetapopt) triggers ferroptosis and inhibits iron-sulfur cluster biogenesis

This paper identifies APR-246's mechanism of inducing ferroptosis and inhibiting iron-sulfur cluster biogenesis through cysteine conjugation in mutant-p53 cancer cells.

Circulating BMP9 protects the pulmonary endothelium during inflammation-induced lung injury in mice

This study shows that BMP9 protects pulmonary endothelium during inflammation-induced lung injury and that exogenous BMP9 can prevent lung injury in mice.

Id proteins promote a cancer stem cell phenotype in triple negative breast cancer via negative regulation of Robo1

This study shows that Id proteins promote a cancer stem cell phenotype in triple negative breast cancer by negatively regulating Robo1, leading to Myc activation.

MicroRNAs as potential therapeutics to enhance chemosensitivity in advancedprostate cancer

This study identifies microRNA mimics that enhance taxane-induced apoptosis in CRPC cell lines, suggesting potential therapeutic use to improve chemosensitivity.