Author

A.-M. Patch

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

A. G. Heriot· 1 shared A. Haque· 1 shared A. Kane· 1 shared A. Puisieux· 1 shared A. SheelaNair· 1 shared B. Cooper· 1 shared B. Knowles· 1 shared B. Leggett· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperCancer Biology

A. G. Heriot

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Targeting of TP53-independent cell cycle checkpoints overcomes FOLFOX resistance in Metastatic Colorectal Cancer

C. Behrenbruch, M. Foroutan, P. Lind, J. Smith, M. Grandin, B. Cooper, C. Shembrey, S. Ramm, K. Cowley, I. Nikolic, J. Liuu, J. Cursons, R. Millen, A.-M. Patch, N. D. Huntington, , F. Hollande

This study identifies FOLFOX resistance in metastatic CRC through cell cycle checkpoint dysregulation and shows that targeting these checkpoints can resensitize resistant organoids to FOLFOX.

bioRxiv · Feb 4, 2021 · PreprintCancer Biology

Th2-like T-follicular helper cells promote functional antibody production during Plasmodium falciparum infection

J.-A. Chan, F. de Labastida Rivera, J. Loughland, J. A. Engel, H. J. Lee, A. SheelaNair, B. Wines, F. Amante, L. Webb, P. Mukhopadhyay, A.-M. Patch, M. Hogarth, J. A. Beeson, J. McCarthy, A. Haque, , M. J. Boyle

The paper identifies Th2-like T-follicular helper cells as key drivers of functional antibody production during Plasmodium falciparum infection, suggesting they are targets for improved malaria vaccines.

bioRxiv · May 18, 2020Immunology

APC Mutation marks an aggressive subtype of BRAF mutant colorectal cancers

L. Fennell, A. Kane, C. Liu, D. Mckeone, W. Fernando, C. Su, C. Bond, S. Jamieson, T. Dumenil, A.-M. Patch, S. Kazakoff, J. Pearson, N. Waddell, B. Leggett, V. Whitehall

This study identifies APC mutations as a marker of aggressive BRAF mutant colorectal cancers, associated with poor prognosis and enhanced tumor growth in mouse models.

bioRxiv · Feb 16, 2020Cancer Biology