Structural insights into TRPV4-Rho GTPase signaling complex function and disease
D. H. Kwon, F. Zhang, B. A. McCray, M. Kumar, J. Sullivan, C. Sumner, S.-Y. Lee
The paper presents cryo-EM structures of TRPV4-RhoA complexes in different states, revealing how their interaction regulates TRPV4 function and contributes to neuromuscular disease.
bioRxiv · Mar 15, 2023 · PreprintBiophysics