M. Kumar

Primary bovine white blood cells support dissemination of Lumpy Skin Disease Virus while suppressing viral replication

This study shows that primary bovine white blood cells support LSDV dissemination but suppress viral replication, with heat-treated virus inducing antiviral gene expression.

Cellulose synthesis in Arabidopsis by heterologous expression of lower plants CESA proteins

This study shows that lower plant CESA proteins can synthesize cellulose in Arabidopsis secondary cell walls, with moss CESA proteins functioning independently but producing less crystalline cellulose.

VIRAL METAGENOMIC SURVEY OF CASPIAN SEALS

This study conducts a viral metagenomic survey of Caspian seals to assess viral diversity and identify potential novel species, finding similarities to other pinniped viromes and reporting new influenza B sequences.

Genomic consequences of isolation and inbreeding in an island dingo population

This study analyzes whole-genome sequences of dingoes on an isolated island to assess the genomic impacts of inbreeding and small population size, finding elevated long runs of homozygosity and evidence of purging deleterious mutations.

Assessing the impact of autologous neutralizing antibodies on rebound dynamics in postnatally SHIV-infected ART-treated infant Rhesus macaques

This study examines how early ART initiation in HIV-infected infants affects antibody development and latent reservoir dynamics, showing their opposing impacts on post-treatment viral rebound.

Comparative Analysis of Within-Host Dynamics of Acute Infection and Viral Rebound Dynamics in Postnatally SHIV-Infected ART-Treated Infant Rhesus Macaques

This study compares acute infection and viral rebound dynamics in ART-treated infant rhesus macaques using a mathematical model to identify increased infected cell death during rebound.

Medication Use is Associated with Distinct Microbial Features in Anxiety and Depression

This study links medication use to distinct gut microbial features in anxiety and depression, showing antidepressants have a larger effect on microbiota than diagnoses.

Binding of SARS-CoV-2 nucleocapsid protein to uninfected epithelial cells induces antibody-mediated complement deposition

This study shows that SARS-CoV-2 nucleocapsid protein binds to uninfected cells, triggering antibody-mediated complement activation in COVID-19 patients.

Expression of Plasmodium Major Facilitator Superfamily Protein in Transporters-Delta Candida Identifies a Drug Transporter

The paper assesses the functional relevance of a Plasmodium MFS protein as a drug transporter using Candida glabrata, showing antifungal resistance and antimalarial properties.

A proteome-wide quantitative platform for nanoscale spatially resolved extraction of membrane proteins into native nanodiscs

This paper introduces a platform for high-throughput extraction of membrane proteins into native nanodiscs while preserving their local membrane context and provides a database for optimized extraction conditions.

Multiomics analysis reveals B. MO1 as a distinct Babesia species and provides insights into its evolution and virulence.

The paper identifies B. MO1 as a distinct Babesia species through multiomics analysis, revealing genomic and functional differences from B. divergens and insights into their evolution and virulence.

A dynamic WUSCHEL / Layer 1 interplay directs shoot apical meristem formation during regeneration

This study identifies the interplay between WUSCHEL and L1 layer formation as critical for de novo shoot apical meristem regeneration in tobacco.

Unraveling molecular basis for reduced neuraminidase inhibitors susceptibility in highly pathogenic avian influenza A (H5N1) viruses isolated from chickens in India

This study identifies mutations in H5N1 avian influenza viruses that confer resistance to neuraminidase inhibitors, revealing their molecular mechanisms and implications for antiviral strategies.

Isolation and Lipidomic Profiling of Neuronal Lipid Droplets: Unveiling the Lipid Landscape of Neurodegenerative Disorders

This paper describes a protocol for isolating and lipidomic profiling of neuronal lipid droplets, revealing their unique lipid composition and potential role in neurodegenerative disorders.

Generation and characterization of a multi-functional panel of monoclonal antibodies for SARS-CoV-2 research and treatment

This paper generates and characterizes three monoclonal antibodies against SARS-CoV-2 RBD, showing varying efficacy in neutralization and detection assays.

Microevolution of clade II isolates of Candida auris highlights multifaceted intra-clade heterogeneity in acquiring resistance towards amphotericin B

This study evolves two clade II Candida auris isolates to develop amphotericin B resistance, revealing distinct mechanisms and intra-clade heterogeneity in resistance acquisition.

iATPSnFR2: a high dynamic range fluorescent sensor for monitoring intracellular ATP

The paper develops iATPSnFR2, a high dynamic range fluorescent ATP sensor for real-time subcellular ATP monitoring, showing improved performance over previous versions.

Non-micellar ganglioside GM1 induces an instantaneous conformational change in Aβ42 leading to the modulation of the peptide amyloid-fibril pathway

This study shows non-micellar GM1 induces a conformational change in Aβ42, modulating its fibril formation pathway and exhibiting prion-like properties.

Guild and Niche Determination Enable Targeted Alteration of the Microbiome

This study introduces a method to classify microbes into guilds and predict their niche preferences using metatranscriptomic and metatranslatomic data, enabling targeted microbiome manipulation.

Structural insights into TRPV4-Rho GTPase signaling complex function and disease

The paper presents cryo-EM structures of TRPV4-RhoA complexes in different states, revealing how their interaction regulates TRPV4 function and contributes to neuromuscular disease.

Eggplant's chlorogenic acid provides resistance against the tropical armyworm

This study identifies chlorogenic acid (CGA) in eggplant as a larvicidal compound effective against the tropical armyworm, with potential as a safe biopesticide.

Genomic signatures of bottleneck and founder effects in dingoes

This study examines genomic signatures of bottleneck and founder effects in dingoes by comparing their whole-genome diversity to other canines, finding lower diversity and higher deleterious mutations in dingoes.

Constrained dynamics of oligonucleotides in the phase-separated droplets

This study uses FCS to measure oligonucleotide dynamics in phase-separated droplets, showing spatial restriction significantly impacts diffusion.

Ganglioside GM1 produces stable, short, and cytotoxic Aβ40 protofibrils

This study shows that GM1 stabilizes short, cytotoxic Aβ40 protofibrils and enhances aggregation of both Aβ40 and Aβ42.

Machine learning assisted ligand binding energy prediction for in silico generated glycosyl hydrolase enzyme combinatorial mutant library

The paper predicts binding energy for combinatorial mutants of an alpha-L-fucosidase using machine learning trained on docking data.

Genomic footprints of bottleneck in landlocked salmon population

This study compares genomic data from landlocked and anadromous salmon populations to show reduced genetic diversity and increased homozygosity in landlocked populations, indicating a historical population bottleneck.

Multispecies autocatalytic RNA reaction networks in coacervates

This study demonstrates the self-reproduction of an RNA system within coacervates, showing catalytic assembly and cross-catalytic activity in multispecies networks, leading to compositional identity and protection against perturbations.

Maximization of Energy Recovery from Starch Processing Wastewater by Thermophilic Dark Fermentation Coupled with Microbial fuel Cell Technology

This study maximizes energy recovery from starch wastewater using thermophilic dark fermentation combined with microbial fuel cells, achieving high hydrogen production and COD reduction.

Metabolic plasticity of T-cell therapies: multi-omic profiling of interacting human tumor-infiltrating lymphocytes and autologous tumor adoptive cell therapy

This study profiles the metabolic interactions between TILs and autologous tumor cells in ACT, finding that responder TILs are more efficient at fatty acid oxidation under starvation.

Structural study of UFL1-UFC1 interaction uncovers the importance of UFL1 N-terminal helix for ufmylation

This study reveals the role of UFL1's N-terminal helix in binding UFC1 and ufmylation, uncovering a helix-mediated regulatory mechanism in the E1-E2-E3 cascade.