Pharmacology & ToxicologybioRxiv
A Peptide Triple Agonist of GLP-1, Neuropeptide Y1, and Neuropeptide Y2 Receptors Promotes Glycemic Control and Weight Loss
K. S. Chichura, C. T. Elfers, T. Salameh…·R. P. Doyle
The paper shows that peptide agonists of GLP-1, Y1-R, and Y2-R improve glycemic control and weight loss in rats, with Y1-R antagonism enhancing GLP-1R effects.
DOI 10.1038/s41598-023-36178-1