M. Ko

Novel Methylation Markers in a Prostate Cancer Cohort are Associated with Disease Development and Relapse

The paper identifies novel methylation markers in a prostate cancer cohort associated with disease development and relapse, showing their predictive power for recurrence.

OpenCap: 3D human movement dynamics from smartphone videos

OpenCap provides an open-source platform to compute human movement dynamics from smartphone videos, enabling accurate prediction of biomechanical metrics at lower cost and faster speed than traditional methods.

Nucleosome patterns in circulating tumor DNA reveal transcriptional regulation of advanced prostate cancer phenotypes

This paper identifies nucleosome patterns in ctDNA that distinguish advanced prostate cancer phenotypes, achieving high accuracy in classification using a prediction model.

Functionally distinct BMP1 isoforms show an opposite pattern of abundance in plasma from non-small cell lung cancer subjects and controls

The paper identifies BMP1 isoforms with opposite abundance patterns in NSCLC and control plasma proteomes, suggesting differential regulation linked to disease progression.

The Endosomal pH Regulator NHE9 is a Driver of Stemness in Glioblastoma

This paper identifies NHE9 as a driver of stemness in glioblastoma by showing it increases receptor tyrosine kinase stability and activates JAK2-STAT3 to induce pluripotency genes.

TMPRSS2 and RNA-dependent RNA polymerase are effective targets of therapeutic intervention for treatment of COVID-19 caused by SARS-CoV-2 variants (B.1.1.7 and B.1.351)

The paper evaluates the effectiveness of TMPRSS2 and RdRp inhibitors against SARS-CoV-2 variants B.1.1.7 and B.1.351, finding they are equally effective as against the original isolate.

Crowdsourced identification of multi-target kinase inhibitors for RET- and TAU- based disease: the Multi-Targeting Drug DREAM Challenge

The paper reports on a DREAM Challenge to predict multi-target kinase inhibitors for RET-based tumors and Tauopathy, using neural network-based machine learning approaches.

Epigenetic Modulation of SPCA2 Reverses Epithelial to Mesenchymal Transition in Breast Cancer Cells

This study shows that histone deacetylase inhibitors increase SPCA2 levels, activate Ca2+ signaling, and reverse epithelial to mesenchymal transition in triple receptor negative breast cancer cells.

Adenosine tips the pathogenic Th1 and Th17 responses in experimental autoimmune uveitis (EAU)

This study shows adenosine enhances Th17 responses while inhibiting Th1 responses in experimental autoimmune uveitis, affecting immune balance through γδ T cells and dendritic cells.

Comparative analysis of antiviral efficacy of FDA-approved drugs against SARS-CoV-2 in human lung cells: Nafamostat is the most potent antiviral drug candidate

Store Independent Ca2+ Entry Regulates the DNA Damage Response in Breast Cancer Cells

This study identifies SPCA2 as a driver of chemotherapy resistance in ER+/p53WT breast cancer by suppressing the DNA damage response through store-independent Ca2+ entry.

Identification of antiviral drug candidates against SARS-CoV-2 from FDA-approved drugs

This study screens 48 FDA-approved drugs for antiviral efficacy against SARS-CoV-2 and identifies 24 drugs with IC50 values between 0.1 M and 10 M, including niclosamide and ciclesonide.

Screening of FDA-approved drugs using a MERS-CoV clinical isolate from South Korea identifies potential therapeutic options for COVID-19

The paper screens FDA-approved drugs against a MERS-CoV isolate to identify potential therapies for COVID-19, finding several drugs with therapeutic indexes >6 and synergistic combinations.

A Ca2+-ATPase Regulates E-cadherin Biogenesis and Epithelial-Mesenchymal Transition in Breast Cancer Cells

This study identifies SPCA2 as a regulator of E-cadherin biogenesis and epithelial-mesenchymal transition in breast cancer, independent of its Ca2+ pump activity.

Single-cell analysis of Crohn’s disease lesions identifies a pathogenic cellular module associated with resistance to anti-TNF therapy

An anti-Gn glycoprotein antibody from a convalescent patient potently inhibits the infection of severe fever with thrombocytopenia syndrome virus

This paper isolates an antibody from a recovered SFTS patient that inhibits multiple SFTSV strains and protects mice from infection, suggesting its potential as a therapeutic agent.