Tuft cells restrain pancreatic tumorigenesis through paracrine eicosanoid signaling
K. E. DelGiorno, C.-Y. Chung, H. C. Maurer, S. Weiser Novak, R. R. Giraddi, D. Wang, R. F. Naeem, L. Fang, L. R. Andrade, N. K. Lytle, W. H. Ali, C. Tsui, V. B. Gubbala, M. Ridinger-Saison, M. Ohmoto, , G. Wahl
This study shows that tuft cells suppress pancreatic tumorigenesis by producing anti-inflammatory prostaglandin D2, which inhibits stromal activation, and identifies their protective role in early disease progression.
bioRxiv · Dec 19, 2019 · PreprintCancer Biology