Cancer BiologybioRxivPreprint
Tuft cells restrain pancreatic tumorigenesis through paracrine eicosanoid signaling
K. E. DelGiorno, C.-Y. Chung, H. C. Maurer…·G. Wahl
This study shows that tuft cells suppress pancreatic tumorigenesis by producing anti-inflammatory prostaglandin D2, which inhibits stromal activation, and identifies their protective role in early disease progression.