Author

N. K. Lytle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Assay:scRNA-seq· 2 Research Focus:cell-cell communication· 1 Organism:human· 1

Frequent Co-Authors

G. Wahl· 3 shared K. E. DelGiorno· 3 shared H. C. Maurer· 2 shared I. Matsumoto· 2 shared K. P. Olive· 2 shared M. C. B. Tan· 2 shared N. Jyotsana· 2 shared P. K. singh· 2 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

G. Wahl

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Author profile →

3 papers

Recent·Most cited

Eicosanoids in the pancreatic tumor microenvironment: a multicellular, multifaceted progression

V. B. Gubbala, N. Jyotsana, V. Q. Trinh, H. C. Maurer, R. F. Naeem, N. K. Lytle, Z. Ma, S. Zhao, W. Lin, H. Han, Y. Shi, T. Hunter, P. K. singh, K. P. Olive, M. C. B. Tan, , K. E. DelGiorno

The paper identifies key eicosanoid changes in pancreatic tumorigenesis and the cell types responsible for their synthesis using mouse models and patient samples.

bioRxiv · Oct 27, 2021Cancer Biology

Single-cell transcriptomics reveals a conserved metaplasia program in pancreatic injury

Z. Ma, N. K. Lytle, B. Chen, N. Jyotsana, S. Weiser Novak, C. J. Cho, L. Caplan, O. Ben-Levy, A. C. Neininger, D. T. Burnette, V. Q. Trinh, M. C. B. Tan, E. A. Patterson, R. Arrojo e Drigo, R. R. Giraddi, , K. E. DelGiorno

The paper uses single-cell RNA sequencing to identify a conserved metaplasia program in pancreatic injury, revealing mucin/ductal populations and neoplastic transformation potential.

bioRxiv · Apr 9, 2021Cell Biology

Tuft cells restrain pancreatic tumorigenesis through paracrine eicosanoid signaling

K. E. DelGiorno, C.-Y. Chung, H. C. Maurer, S. Weiser Novak, R. R. Giraddi, D. Wang, R. F. Naeem, L. Fang, L. R. Andrade, N. K. Lytle, W. H. Ali, C. Tsui, V. B. Gubbala, M. Ridinger-Saison, M. Ohmoto, , G. Wahl

This study shows that tuft cells suppress pancreatic tumorigenesis by producing anti-inflammatory prostaglandin D2, which inhibits stromal activation, and identifies their protective role in early disease progression.

bioRxiv · Dec 19, 2019 · PreprintCancer Biology