AbNatiV: VQ-VAE-based assessment of antibody and nanobody nativeness for hit selection, humanisation, and engineering
A. Ramon, M. Ali, M. Atkinson, A. Saturnino, K. Didi, C. Visentin, S. Ricagno, X. Xu, M. Greenig, P. Sormanni
AbNatiV assesses antibody and nanobody nativeness using a VQ-VAE model, enabling hit selection, humanisation, and engineering with improved performance over conventional methods.
bioRxiv · Apr 28, 2023 · PreprintBioengineering