BiochemistrybioRxiv
Complete Reconstitution and Deorphanization of the 3 MDa NOCAP (NOCardiosis-Associated Polyketide) Synthase
K. P. Yuet, C. W. Liu, S. R. Lynch…·C. Khosla
The paper reconstitutes and deorphanizes a nonamodular PKS from Nocardia strains, identifying the NOCAP aglycone structure through in vitro and heterologous expression methods.
DOI 10.1021/jacs.0c00904