Author

C. Khosla

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 6 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 7 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

B. A. Palanski· 2 shared K. P. Yuet· 2 shared S. R. Lynch· 2 shared A. Christophersen· 1 shared A. D. D'Souza· 1 shared A. E. McShane· 1 shared A. Gupta· 1 shared A. J. Hilmer· 1 shared

Activity by Year

2018-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 7 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersImmunology

B. A. Palanski

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Structural Basis for Intermodular Communication in Assembly-Line Polyketide Biosynthesis

D. P. Cogan, A. M. Soohoo, M. Chen, Y. Liu, K. L. Brodsky, C. Khosla

The paper investigates intermodular communication in polyketide biosynthesis using cryo-EM and crosslinking, revealing structural insights for designing hybrid synthases.

bioRxiv · May 5, 2024Biochemistry

Human KIR+CD8+ T cells target pathogenic T cells in Celiac disease and are active in autoimmune diseases and COVID-19

J. Li, M. E. Zaslavsky, Y. Su, M. Sikora, V. van Unen, A. Christophersen, S.-H. Chiou, L. Chen, J. Li, X. Ji, J. Wilhelmy, A. McSween, B. A. Palanski, V. Mallajosyula, G. Dhondalay, , M. Davis

The paper identifies KIR+CD8+ T cells as regulatory cells in humans that suppress pathogenic CD4+ T cells in autoimmune and infectious diseases.

bioRxiv · Dec 23, 2021 · PreprintImmunology

An efficient urine peptidomics workflow identifies chemically defined dietary gluten peptides from patients with celiac disease

B. A. Palanski, N. Weng, L. Zhang, A. J. Hilmer, L. A. Fall, K. Swaminathan, B. Jabri, C. Sousa, N. Q. Fernandez-Becker, C. Khosla, J. E. Elias

The paper develops a urine peptidomics workflow to identify chemically defined dietary gluten peptides in celiac disease patients, revealing differences from controls.

bioRxiv · Mar 17, 2021Biochemistry

Analysis of a "Split-and-Stuttering" Module of an Assembly Line Polyketide Synthase

K. M. Guzman, K. P. Yuet, S. R. Lynch, C. Liu, C. Khosla

The paper investigates a 'split-and-stuttering' module of a trans-AT PKS, showing it can catalyze up to five elongation cycles with a cis-configured central olefinic group after three cycles.

bioRxiv · Jan 15, 2021 · PreprintBiochemistry

Enhancing the Antiviral Efficacy of RNA-Dependent RNA Polymerase Inhibition by Combination with Modulators of Pyrimidine Metabolism

Q. Liu, A. Gupta, A. Okesli-Armlovich, W. Qiao, C. Fischer, M. Smith, J. E. Carette, M. C. Bassik, C. Khosla

The paper identifies DHODH as a target of GSK983 and shows that combining it with pyrimidine salvage inhibitors like CPU enhances antiviral efficacy against dengue virus.

bioRxiv · Mar 24, 2020Biochemistry

Complete Reconstitution and Deorphanization of the 3 MDa NOCAP (NOCardiosis-Associated Polyketide) Synthase

K. P. Yuet, C. W. Liu, S. R. Lynch, J. Kuo, W. Michaels, R. B. Lee, A. E. McShane, B. L. Zhong, C. R. Fischer, C. Khosla

The paper reconstitutes and deorphanizes a nonamodular PKS from Nocardia strains, identifying the NOCAP aglycone structure through in vitro and heterologous expression methods.

bioRxiv · Jan 28, 2020Biochemistry

Engineering of chimeric polyketide synthases using SYNZIP docking domains

M. Klaus, A. D. D'Souza, A. Nivina, C. Khosla, M. Grininger

This study compares chimeric PKSs with different interfaces to identify the least invasive method for PKS engineering, showing that SYNZIP domains can effectively replace natural docking domains.

bioRxiv · Dec 7, 2018Biochemistry