Alpha-ketoglutarate, an endogenous metabolite, extends lifespan and compresses morbidity in aging mice
A. Asadi Shahmirzadi, D. Edgar, C.-Y. Liao, Y.-M. Hsu, M. Lucanic, A. Asadi Shahmirzadi, C. Wiley, R. Riley, G. Gan, C. Kuehnemann, D. Bhaumik, G. J. Lithgow, B. K. Kennedy
This study shows that alpha-ketoglutarate extends lifespan and healthspan in aging mice by reducing frailty and inflammatory factors.
bioRxiv · Oct 4, 2019Cell Biology