Cell BiologybioRxiv
Alpha-ketoglutarate, an endogenous metabolite, extends lifespan and compresses morbidity in aging mice
A. Asadi Shahmirzadi, D. Edgar, C.-Y. Liao…·B. K. Kennedy
This study shows that alpha-ketoglutarate extends lifespan and healthspan in aging mice by reducing frailty and inflammatory factors.
DOI 10.1016/j.cmet.2020.08.004