G. J. Lithgow

β-hydroxybutyrate is a metabolic regulator of proteostasis in the aged and Alzheimer disease brain

This study identifies β-hydroxybutyrate as a metabolic regulator of protein solubility in aging and Alzheimer's disease, showing it reduces insolubility of pathological proteins like amyloid-β.

The coupling between healthspan and lifespan in Caenorhabditis depends on complex interactions between compound intervention and genetic background

This study evaluates how compound interventions and genetic background affect healthspan and lifespan in C. elegans under stress conditions.

Antioxidants green tea extract and nordihydroguaiaretic acid confer species and strain specific lifespan and health effects in Caenorhabditis nematodes

This study evaluates the lifespan and health effects of five compounds in Caenorhabditis nematodes, finding species- and strain-specific responses, assay-dependent outcomes, and uncoupling of lifespan and health effects.

Potassium-chelating drug sodium polystyrene sulfonate enhances lysosomal function and suppresses proteotoxicity

This study shows that the FDA-approved drug sodium polystyrene sulfonate enhances lysosomal function and reduces proteotoxicity in C. elegans and human neuronal cells, while also increasing lifespan.

Alpha-ketoglutarate, an endogenous metabolite, extends lifespan and compresses morbidity in aging mice

This study shows that alpha-ketoglutarate extends lifespan and healthspan in aging mice by reducing frailty and inflammatory factors.

Automated Lifespan Determination Across Caenorhabditis Strains and Species Reveals Assay-Specific Effects of Chemical Interventions

The paper compares manual and automated lifespan assays in Caenorhabditis strains, finding that automated methods reproduce results but show assay-specific effects of chemical interventions.