C.-Y. Liao

TCR-engineered T-cells directed against Ropporin-1 constitute a safe and effective treatment for triple-negative breast cancer in near-clinical models

This study identifies ROPN1 as a target for TCR-engineered T-cells effective against TNBC in preclinical models and demonstrates their safety and efficacy.

Differential leaf flooding resilience in Arabidopsis thaliana is controlled by age-dependent ORESARA1 activity

This paper shows that in flooded Arabidopsis, ethylene triggers senescence only in old leaves through ORE1 activation, despite systemic ethylene accumulation.

Integration of multi-omics data reveals interplay between brassinosteroid and TORC signaling in Arabidopsis

The paper integrates multi-omics data to uncover molecular interactions between BR and TORC signaling in Arabidopsis, revealing shared regulatory mechanisms in growth and stress responses.

Local light signalling at the leaf tip drives remote differential petiole growth through auxin-gibberellin dynamics

The paper shows that light signals at the leaf tip drive differential petiole growth through auxin and gibberellin dynamics, enabling upward leaf movement.

Brassinosteroids modulate autophagy through phosphorylation of RAPTOR1B by the GSK3-like kinase BIN2 in Arabidopsis

This study shows that brassinosteroids modulate autophagy in Arabidopsis by phosphorylating RAPTOR1B via BIN2 kinase, linking BR signaling to TOR-mediated autophagy regulation.

Interplay between brassinosteroids and TORC signaling in Arabidopsis revealed by integrated multi-dimensional analysis

This study identifies crosstalk between brassinosteroid and TORC signaling in Arabidopsis through multi-omics analysis of mutants, revealing shared gene-products and a kinase signaling network.

A molecular framework for control of oriented cell division in the Arabidopsis embryo

This study identifies auxin's role in controlling division plane orientation in Arabidopsis embryos through cytoskeleton remodeling and cell geometry.

Alpha-ketoglutarate, an endogenous metabolite, extends lifespan and compresses morbidity in aging mice

This study shows that alpha-ketoglutarate extends lifespan and healthspan in aging mice by reducing frailty and inflammatory factors.