Author

D. Edgar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:C. elegans· 2 Research Focus:benchmarking· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:host-pathogen & immune response· 1 Assay:imaging· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1

Frequent Co-Authors

G. J. Lithgow· 3 shared M. Lucanic· 3 shared A. C. Foulger· 2 shared A. L. Coleman-Hulbert· 2 shared B. Onken· 2 shared C. A. Sedore· 2 shared D. Bhaumik· 2 shared D. Hall· 2 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersPhysiology

G. J. Lithgow

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Antioxidants green tea extract and nordihydroguaiaretic acid confer species and strain specific lifespan and health effects in Caenorhabditis nematodes

S. A. Banse, C. A. Sedore, E. Johnson, A. L. Coleman-Hulbert, B. Onken, D. Hall, E. G. Jackson, P. Huynh, A. C. Foulger, S. Guo, T. Garrett, J. Xue, D. Inman, M. L. Morshead, W. T. Plummer, , P. C. Phillips

This study evaluates the lifespan and health effects of five compounds in Caenorhabditis nematodes, finding species- and strain-specific responses, assay-dependent outcomes, and uncoupling of lifespan and health effects.

bioRxiv · Nov 9, 2021Physiology

Alpha-ketoglutarate, an endogenous metabolite, extends lifespan and compresses morbidity in aging mice

A. Asadi Shahmirzadi, D. Edgar, C.-Y. Liao, Y.-M. Hsu, M. Lucanic, A. Asadi Shahmirzadi, C. Wiley, R. Riley, G. Gan, C. Kuehnemann, D. Bhaumik, G. J. Lithgow, B. K. Kennedy

This study shows that alpha-ketoglutarate extends lifespan and healthspan in aging mice by reducing frailty and inflammatory factors.

bioRxiv · Oct 4, 2019Cell Biology

Automated Lifespan Determination Across Caenorhabditis Strains and Species Reveals Assay-Specific Effects of Chemical Interventions

S. A. Banse, M. Lucanic, C. A. Sedore, A. L. Coleman-Hulbert, W. T. Plummer, E. Chen, J. L. Kish, D. Hall, B. Onken, M. P. Presley, E. G. Jones, B. W. Blue, T. Garrett, M. Abbott, J. Xue, , P. C. Phillips

The paper compares manual and automated lifespan assays in Caenorhabditis strains, finding that automated methods reproduce results but show assay-specific effects of chemical interventions.

bioRxiv · Sep 14, 2019Physiology