Insulin dissociates by diverse mechanisms of coupled unfolding and unbinding
A. Antoszewski, C.-J. Feng, B. Vani, E. H. Thiede, L. Hong, J. Weare, A. Tokmakoff, A. R. Dinner
This study uses molecular dynamics simulations to investigate insulin dimer dissociation mechanisms, revealing multipathway behavior with conformational selection and induced fit as limiting cases.
bioRxiv · Mar 16, 2020Biophysics