L. Jin

FLT3 is genetically essential for ITD-mutated leukemic stem cells but dispensable for human hematopoietic stem cells

This study shows FLT3 is essential for ITD-mutated leukemic stem cells but not for normal hematopoietic stem cells, supporting targeted therapies for AML.

Brain implantation of tissue-level-soft bioelectronics 1 via embryonic development

This paper introduces a stretchable microelectrode array that integrates into the developing brain, enabling long-term, stable neural activity tracking without disrupting development.

Adipocyte microRNA-802 promotes adipose tissue inflammation and insulin resistance by modulating macrophages in obesity

This study shows that miR-802 in adipose tissue promotes inflammation and insulin resistance by modulating macrophage recruitment and polarization in obesity.

NK Cell Exhaustion in Wilson's Disease Revealed by Single-cell RNA Sequencing Predicts the Prognosis of Cholecystitis

This study uses single-cell RNA sequencing to show NK cell exhaustion in Wilson's disease is linked to worse cholecystitis outcomes.

Machine learning-inferred and energy landscape-guided analyses reveal kinetic determinants of CRISPR/Cas9 gene editing

This study combines machine learning and energy landscape analysis to identify kinetic determinants of CRISPR/Cas9 gene editing, revealing a three-state mechanism and critical nucleotides for cleavage efficiency.

Image-based Strain Analysis Reveals Intracellular Strain Controlled by Nucleo-Cytoskeletal Coupling

This study measures intracellular strain using microscopy and finds an inverse relationship between cytoplasmic and nuclear strains controlled by nucleo-cytoskeletal coupling.

The stability of lower genital tract microbiota correlates with reproductive system function and in vitro fertilization and frozen embryo transfer outcomes in women with polycystic ovarian syndrome

This study investigates the relationship between lower genital tract microbiota and reproductive outcomes in PCOS patients, finding that higher Lactobacillus abundance correlates with better IVF-FET outcomes.

CCT3 drives Sorafenib resistance by inhibiting TFRC-mediated iron uptake in HCC

This study identifies CCT3 as a driver of Sorafenib resistance in HCC by inhibiting TFRC-mediated iron uptake, leading to ferroptosis resistance.

How hibernation in frogs drives brain and reproductive evolution in opposing directions

This study shows that prolonged brumation in frogs is associated with reduced brain size and increased reproductive investment, highlighting opposing evolutionary pressures in resource allocation.

NK and NKT cells in the pathogenesis of Hidradenitis suppurativa: Novel therapeutic strategy through targeting of CD2

This study identifies expanded NKT and NK cells with elevated CD2 in HS lesions and shows CD2 blockade reduces inflammation and fibrosis.

The common TMEM173 HAQ, AQ alleles rescue CD4 T cellpenia, restore T-regs, and prevent SAVI (N153S) inflammatory disease in mice.

This study shows that common TMEM173 alleles HAQ and AQ reduce inflammation in SAVI mice by preventing CD4 T cell depletion and restoring T-regs.

Identification of a human hematopoietic stem cell subset that retains memory of inflammatory stress

The paper identifies a human HSC subset with inflammatory memory that accumulates with age and clonal hematopoiesis, potentially increasing cancer and infection risks.

Unraveling Vulnerabilities in Endocrine Therapy-Resistant HER2+/ER+ Breast Cancer

The paper develops two in vitro models of endocrine therapy-resistant HER2+/ER+ breast cancer and identifies lipid metabolism and ferroptosis as therapeutic vulnerabilities.

Different coexistence patterns between apex carnivores and mesocarnivores based on temporal, spatial, and dietary niche partitioning analysis in Qilian Mountain National Park, China

Optogenetic strategies for optimizing the performance of biosensors of membrane phospholipids in live cells

This paper presents optogenetic strategies to enhance phospholipid biosensors in live cells by reducing background signals and amplifying detection through light-controlled probe release and phase separation.

A force-sensitive mutation reveals a spindle assembly checkpoint-independent role for dynein in anaphase progression

This study identifies a mutation in dynein that causes mitotic spindle arrest independent of the spindle assembly checkpoint, revealing a load-dependent role in anaphase progression.

Augmented Super-Resolution Radial Fluctuations (aSRRF) Pushing the Limits of Structured Illumination Microscopy

The paper introduces aSRRF, a method that enhances SIM resolution to ~50 nm isotropically using image augmentation without changing the optical setup or sample acquisition.

Mechanism of ozone alleviation of malignant ascites in hepatocellular carcinoma through inhibition of NETs

This study shows ozone reduces malignant ascites in hepatocellular carcinoma by inhibiting NETs through AMPK activation and SR-A mediated phagocytosis of DAMPs.

HEATR5B associates with dynein-dynactin and selectively promotes motility of AP1-bound endosomal membranes

This study identifies HEATR5B as a novel dynein-dynactin interactor that promotes AP1-bound endosomal membrane motility and Golgi transport in human and Drosophila cells.

Three-Dimensional Bioconjugated Liquid-Like Solid (LLS) Enhance Characterization of Solid Tumor - Chimeric Antigen Receptor T cell Interactions

This study uses 3D bioconjugated liquid-like solids to model tumor-immune interactions, showing CAR T cells can infiltrate and kill cancer cells while revealing immune escape mechanisms.

Deep learning permits imaging of multiple structures with the same fluorophores

The paper introduces DBSN, a deep learning method that enables imaging of multiple subcellular structures using only two fluorescent labels, overcoming spectral overlap limitations.

Cell dichotomous role of STING in pulmonary hypertension

This study investigates the role of STING in pulmonary hypertension, finding that STING overactivation contributes to disease while global deficiency protects against it, with distinct cellular roles in smooth muscle and myeloid cells.

Complexes Formed by Mixing Tumor-derived Extracellular Vesicles with Polymeric Surfactants for Personalized Therapeutic Vaccine

This paper develops a therapeutic vaccine using tumor-derived extracellular vesicles modified with polymeric surfactants to enhance immunogenicity and efficacy against melanoma.

The cellular Notch1 Protein Promotes KSHV reactivation in an Rta-dependent manner.

This study shows that constitutive Notch activity is required for KSHV reactivation, with Notch1 promoting viral production through interactions with Rta and RBP-Jk.

Disulfide stabilization reveals conserved dynamic features between SARS-CoV-1 and SARS-CoV-2 spikes.

This study introduces disulfides into SARS-CoV-1 spike protein to stabilize locked conformations, revealing conserved structural features with SARS-CoV-2.

Co-targeting BCL-XL and MCL-1 with DT2216 and AZD8055 synergistically inhibits small-cell lung cancer growth without causing on-target toxicities in mice

Semi-Self-Supervised Learning for Semantic Segmentation in Images with Dense Patterns

The paper proposes a semi-self-supervised learning method for wheat head segmentation using minimal manual annotations and achieves high Dice scores on both internal and external datasets.

A Practical Approach for Optimizing Off-axis Telecentric Digital Holographic Microscope Design

This paper introduces methodologies to optimize the design and alignment of telecentric digital holographic microscopes by determining the optimal +1 order position, verified using living HeLa cells.

KDM6A loss sensitizes human acute myeloid leukemia to PARP and BCL2 inhibition

This study shows that KDM6A loss in AML increases sensitivity to PARP and BCL2 inhibitors, suggesting a new combination therapy approach for KDM6A-mutant AML.

A chemical molecule promotes Trop2+ biliary duct organoids differentiation into insulin-secreting cells

This paper shows a chemical molecule enhances the differentiation of biliary duct organoids into insulin-secreting cells, improving glucose sensitivity in diabetic mice.