NeurosciencebioRxivPreprint
Novel mouse model reveals neurodevelopmental origin of PMM2-CDG brain pathology
Andrew C. Edmondson, Rohit Budhraja, Zijie Xia…·Zhaolan Zhou
This study creates a mouse model of PMM2-CDG by selectively removing PMM2 from neural precursor cells, revealing cerebellar hypoplasia and ataxia, and showing molecular disturbances in the cerebellum that mirror human disease.
3 citations