BiochemistryNature CommunicationsPeer-reviewed
Hypertrophic cardiomyopathy mutations Y115H and E497D disrupt the folded-back state of human beta-cardiac myosin allosterically
Neha Nandwani, Debanjan Bhowmik, Camille Glaser…·Kathleen M. Ruppel
This study investigates how HCM mutations Y115H and E497D disrupt the folded-back state of human beta-cardiac myosin, leading to hypercontractility by destabilizing the OFF-state.
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