Author

Neha Nandwani

Stanford MedicineORCID 0000-0002-6958-3756Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Assay:proteomics· 1

Frequent Co-Authors

Aminah DawoodiD· 2 shared James A. SpudichiD· 2 shared Kathleen M. RuppeliD· 2 shared Rama Reddy GoluguriiD· 2 shared Anne HoudusseiD· 1 shared Camille Glaser· 1 shared David Dale ThomasiD· 1 shared Debanjan BhowmikiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersBiochemistry

Aminah DawoodORCID

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2 papers

Recent·Most cited

BiochemistryNature CommunicationsPeer-reviewedOct 1, 2025

Hypertrophic cardiomyopathy mutations Y115H and E497D disrupt the folded-back state of human beta-cardiac myosin allosterically

Neha Nandwani, Debanjan Bhowmik, Camille Glaser…·Kathleen M. Ruppel

This study investigates how HCM mutations Y115H and E497D disrupt the folded-back state of human beta-cardiac myosin, leading to hypercontractility by destabilizing the OFF-state.

16 citationstop 2%

humanproteomics

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BiophysicsbioRxivPreprintDec 5, 2024

A FRET assay to quantitate levels of the human β-cardiac myosin interacting heads motif based on its near-atomic resolution structure

Rama Reddy Goluguri, Piyali Guhathakurta, Neha Nandwani…·Kathleen M. Ruppel

The paper develops a FRET assay to directly quantify the IHM state of human β-cardiac myosin and shows how mutations and perturbations affect its stability.

7 citations

humanexperimental assay

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