ImmunologybioRxivPreprint
Rational design of a SOCS1-edited tumor infiltrating lymphocyte therapy for solid tumors using CRISPR/Cas9 screens
Michael R. Schlabach, Sharon Lin, Zachary Collester…·Micah J. Benson
This study uses CRISPR/Cas9 screens to identify SOCS1 as a target for enhancing T cell therapy, leading to the development of an engineered TIL therapy with improved anti-tumor function.
DOI 10.1101/2023.09.05.555798