Carolyn Roche

This paper shows polymicrobial extracellular vesicles enhance virulence and inflammation in CF bronchial epithelial cells, and modulator therapy ETI does not reverse this effect.

This study shows that Bacteroides fragilis outer membrane vesicles reduce CFTR Cl- secretion in human colon organoids, with BFT-2-containing vesicles being more effective.

This study shows that mesenchymal stromal cell-derived extracellular particles reduce Pseudomonas aeruginosa lung infection and inflammation in a cystic fibrosis mouse model.

This study shows ETI increases defensin gene expression and reduces MMP10, MMP12, and inflammatory signaling in CF airway epithelial cells.

This paper shows tobramycin reduces inflammation in cystic fibrosis by increasing 5' tRNA-fMet halves in P. aeruginosa outer membrane vesicles, which suppress IL-8 and neutrophilic inflammation in human cells and mice.