Carrie A. Sheeler

This study identifies FLP-17, a neuropeptide that mediates cell non-autonomous UPRER activation in C. elegans, protecting against ER stress and protein aggregation.

This study identifies brain regions and cell types contributing to SCA1 disease using conditional knockout mice, showing that targeting multiple areas and muscle is necessary for effective therapy.

This study examines spatiotemporal changes in astrocyte phenotypes in SCA1 mice, finding region-specific alterations in astrocyte function and homeostasis that may contribute to disease progression.

The paper identifies regional transcriptional and physiological differences in Purkinje cells of the cerebellum in SCA1 mice, showing reduced heterogeneity and increased vulnerability in the posterior cerebellum.