Molecular BiologyFrontiers in Genome EditingPeer-reviewed
Lentiviral CRISPRa/i in the adult Prairie Vole Brain: Modulating Neuronal Gene Expression Without DNA Cleavage
Meredith K. Loth, Kendall T. Mesch, Celine Herrera-Garcia…·Zoe R. Donaldson
This paper develops a lentiviral CRISPRa/i system for non-mutagenic gene regulation in prairie voles, demonstrating bidirectional modulation of social behavior-related genes in specific brain regions.
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